Study of Pulmonary Functions, Arterial Blood Gases and Autonomic Functions in Chronic Obstructive Pulmonary Disease and its Comparison Between Young and Elderly Patients

Dr Naveen Kishoria, Dr Kumari Doully, Dr Harish Agarwal

Abstract


Purpose of the study: Chronic Obstructive Pulmonary Disease (COPD) is one of the most important causes
of morbidity and mortality worldwide. Purpose of this study is to compare the Pulmonary functions, Autonomic
functions and Arterial Blood Gases (ABG) between young and elderly COPD patients and to determine association if any between severity
of the disease and autonomic dysfunctions.
Methods: In this cross sectional study a total of hundred male patients attending medical OPD (Fifty young and fifty Old) who has diagnosis
of COPD were included. This study was carried out in the outpatient setting in a tertiary referral Mathura Das Mathur Hospital,
Jodhpur. Spirometry, arterial blood gas analysis and autonomic functions were assessed.
Result: The severity of COPD was more among elderly population as compared to young patients. The risk of development of co-morbidities
and acute exacerbations also was more among the elderly. The study also demonstrated a high prevalence (97%) of early and definite
cardiac autonomic neuropathy among patients suffering from COPD. The autonomic dysfunction developed independent of the age of
the patients suggesting that COPD is responsible for earlier onset of cardiac autonomic neuropathy. The autonomic dysfunction does not
depend upon the degree of airway limitation (FEV1). The prevalence of autonomic dysfunction did not show any significant correlation
with the presence of hypoxia.


Keywords


Chronic obstructive pulmonary disease, autonomic nervous system, Arterial blood gas, pulmonary function

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