PRIMARY LEIOMYOSARCOMA OF BONE OF SACRUM: A RARE CASE REPORT

Dr Prajwal R, Dr Diptajit Paul, Dr Keerthan, Dr Rakesh Dhankhar

Abstract


Introduction: Primary leiomyosarcoma of the bone (PLB) is an extremely rare, invasive, and shows highly aggressive
behaviour with limited treatment options and without appropriate treatment has poor prognosis. PLB most commonly
affects bones around the knee joint, usually originating from smooth muscle tissue, though its exact origin within bones remains unclear. The
molecular entity and biological properties of LMS have not yet been claried. We are hereby reporting a rare case of PLB in women. Case
Summary: A 51-year-old female bounded to wheel chair presented to Radiation Oncology out-patient department (OPD) with lower back pain.
On radiological evaluation with MRI, it showed expansile mass lesion involving right sacrum and ilium. After evaluating her symptoms, she
underwent biopsy of sacral lesion it was diagnosed primary leiomyosarcoma of bone. After thorough evaluation she received palliative radiation
therapy followed by combination chemotherapy of 6 courses. Conclusion: PLBs are rare in nature and dedicated clinical trials must undertake
with integration of chemotherapy, radiation and surgery. The multi-disciplinary approach should be enforced to give maximum benet to patient
diagnosed with PLB.


Keywords


Primary leiomyosarcoma of bone, chemotherapy, radiation therapy

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